Zonation of fatty acid metabolism in rat liver
نویسندگان
چکیده
منابع مشابه
Flexibility of zonation of fatty acid oxidation in rat liver.
Periportal and perivenous hepatocytes were isolated from rats subjected to different treatments that induce (starvation, cold exposure) or depress (refeeding after starvation) hepatic fatty acid oxidation. These experiments were designed to determine factors that may be involved in creating and maintaining the asymmetrical distribution of this metabolic pathway in the acinus of the liver. The u...
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1. The formation of acetoacetate, beta-hydroxybutyrate and glucose was measured in the isolated perfused rat liver after addition of fatty acids. 2. The rates of ketone-body formation from ten fatty acids were approximately equal and independent of chain length (90-132mumol/h per g), with the exception of pentanoate, which reacted at one-third of this rate. The [beta-hydroxybutyrate]/[acetoacet...
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BACKGROUND Plasma free fatty acids (FFA) are involved in blood lipid metabolism as well as many health complications. The present study was conducted to evaluate the potential role of chlorogenic acid complex from green coffee bean (CGA7) on FFA metabolism in high fat diet fed rats. METHODS Hyperlipidemia was induced in Wistar rats using high-fat diet. The animals were given CGA7/orlistat con...
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In an attempt to clarify the hepatic insufficiency in obstructive jaundice, hepatic metabolic rate of n-butyric acid, ketogenesis and CO2 formation from butyric acid were investigated using liver slices obtained from rats subjected to choledochal ligation or carbon tetrachloride (CCl4) injection. The hepatic metabolic rate of n-butyric acid was reduced with the prolongation of biliary obstructi...
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Imatinib is an orally administered tyrosine kinase inhibitor which inhibits the Bcr-Abl protein-tyrosine kinase with high selectivity. Imatinib is rapidly absorbed from the gut, after oral intake and has an almost absolute bioavailability of 98%. The metabolism of imatinib is mediated by the cytochrome P450 (CYP) isoenzymes in the liver and gut wall. CGP74588 is a major active metabolite of ima...
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ژورنال
عنوان ژورنال: Biochemical Journal
سال: 1989
ISSN: 0264-6021,1470-8728
DOI: 10.1042/bj2640107